Table 5.
Summary of 3 way integrated analysis of Gene-Expression-SNP and triptolide cytotoxicity (p < 0.0001)
| Gene expression (Gene symbol) | Gene description | Association with total # of SNPs (p < 0.0001) | Distribution of SNPs (Chr: number of SNPs) | Distribution of SNPs on gene (Bold indicates Maximum number of SNPs on Gene) |
|---|---|---|---|---|
| AGL (Chr1) | Amylo-Alpha-1, 6-Glucosidase, 4-Alpha-Glucanotransferase | 27 | Chr2:1 / Chr4:2 / Ch6:2 / Chr16:22 | CHST5/ADAT1/GABARAPL2/LRP2/SCGN/TMEM231 |
| ASCL4 (Chr12) | Achaete-Scute Complex-Like 4 | 24 | Chr6:5 / Chr7:1 / Ch9:1 / Chr16:2 / Chr17:3 / Chr18:12 | MPG/ASXL3/ATP6V0A1/EEPD1/MPG/NAGLU |
| C21orf96/RUNX-IT1 (Chr21) | RUNX1 Intronic Transcript 1 (Non-Protein Coding) | 3 | Chr5:1 / Chr9:1 / Chr13:1 | PDZD2 |
| C9orf19/GLIPR2 (Chr9) | Glioma Pathogenesis-Related Protein 2 | 20 | Chr1:2 / Chr2:6 / Chr5, 7, 11 and 14 : 1 each / Chr8:3 / Chr12:2 / Chr13:3 | ARRB1 / CAPN2 / CFLAR/ TP53BP2 |
| CRYGS (Chr3) | crystallin, gamma S | 41 | Chr1:30 Chr2 and Chr6: 3 each Chr5:2 Chr8, 9 and 14: 1 each | CAMTA1 |
| CTSK (Chr1) | Cathepsin X | 19 | Chr1,9 and 16:1 each/ Chr5:6/ Chr7, 10 and 17: 2 each/ Chr14: 4 each | CRISPLD2/FHAD1/IDE/PTPRD/RBFOX3/SNX6/SP4 |
| DTX1 (Chr12) | deltex homolog 1 (Drosophila) | 31 | Chr 6:5 / Chr 9:1 / Chr 14:2 / Chr 21:23 | TIAM1 |
| FOXQ1 (Chr6) | Forkhead Box Protein Q1 | 21 | Chr 1:6 / Chr 3:10 / Chr 5 and 6:1 each / Chr 16:3 | FLYWCH1/GNG4/PARK2 |
| GABARAPL1 (Chr12) | GABA(A) Receptor-Associated Protein-Like 1 | 7 | Chr 2:5 / Chr 6 and 14:1 each | STRN3 |
| JAK1 (Chr1) | Janus Kinase 1 | 44 | Chr 1:8 / Chr 2, 3, 6 and 10:2 each/ Chr 4, 12 and 13:1 each / Chr 5:12 / Chr 8:3 / Chr 14:10 | GPATCH2/ SLC6A15/ TFDP2 |
| MAPKAPK2 (Chr1) | Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 | 3 | Chr11:2 / Chr 5:1 | ARRB1/ OPCML |
| MGC16186 (Chr10) | DPY30 Domain Containing 2 | 10 | Chr 4:4 / Chr 7, 9 and 22:1 each / Chr 10:3 | MANBA/ MYO18B |
| MGC16385 (Chr16) | CENPB DNA-Binding Domains Containing 1 | 18 | Chr 4:4 / Chr 5:2 / Chr 17 and 22:1 each / Chr 14:10 | AGXT2L1/ GIP / ITPK1/PDE6A |
| MTND4 (mitochondrial) | Mitochondrially Encoded NADH Dehydrogenase | 16 | Chr 1:8 / Chr 4, 6, 8, 9 and 14:1 each / Chr 10:3 | GNG4/ GPATCH2/ SH2D4B |
| MTND5 (mitochondrial) | Mitochondrially Encoded NADH Dehydrogenase 5 | 10 | Chr 9 and 10:1 / Chr 14:8 | PTGDR / SH2D4B |
| MTVR1 (Chr11) | Mammary Tumor Virus Receptor Homolog 1 | 28 | Chr 2:23 / Chr 6 and 10:1 each / Chr 7:3 | NIF3L1/ C7orf42/ CFLAR/ FAM126B/NIF3L1/ORC2 |
| MUC15 (Chr11) | Mucin 15, Cell Surface Associated | 16 | Chr 1:8 / Chr 2:2 / Chr 9, 15 and 21:1 each / Chr 11:3 | CAPN2/CGNL1/TP53BP2 |
| MXD4 (Chr4) | MAX dimerization protein 4 | 13 | Chr 2:3 / Chr 4, 5, 10 and 17:1 each / Chr 9:2 / Chr 16:4 | MPG/NPRL3/CCDC46/KANK1/USP34 |
| NADSYN1 (Chr11) | NAD Synthetase 1 | 38 | Chr 2:32 / Chr 13:1 / Chr 16:5 | ERBB4/ FHAD1/ GPATCH2 |
| PIP5K1B (Chr9) | Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta | 75 | Chr 1:2 / Chr 2: 65 / Chr 6 and 14:1 each / Chr 7:4 / Chr 13:2 | NIF3L1/ ABCC4/ CFLAR/ FAM126B/ GPATCH2/NDUFB3/NIF3L1/ORC2/PPIL3/SMYD3/TSGA14 |
| PODLX2 (Chr3) | podocalyxin-like 2 | 44 | Chr 3 and 20:1 each / Chr 11:39 / Chr 11:3 | LDLRAD3 |
| ROPN1 (Chr3) | Rhophilin Associated Tail Protein 1 | 7 | Chr 1:2 / Chr 3:3 / Chr 4 and 13:1 | |
| SLC35D2 (Chr9) | Solute Carrier Family 35 Member D2 | 18 | Chr 4 and 10:3 each / Chr 5:10 / Chr 13 and 22:1 each | ABLIM2/ MANBA/ TTLL1 |
| TDE1 (Chr20) | Tumor Differentially Expressed 1 | 39 | Chr 1:12 / Chr 2, 10and 14:1 each / Chr 3:6 / Chr 5:9 / Chr 8:7 / Cht 15:2 | FHAD1/PPCS/ SMYD3/ZMYND12 |
| TWSG1 (Chr18) | Twisted Gastrulation Protein Homolog 1 | 8 | Chr 2:5 / Chr 6:3 | CLK1/ FAM126B/ |
| VIAAT (Chr20) | Solute Carrier Family 32 Member 1 | 55 | Chr 6 and 10:4 each / Chr 12:1 / Chr 13: 3 / Chr 14:41 / Chr 16:2 | SNX6/ STRN3/ RSU1 |
| VPS39 (Chr15) | Vacuolar Protein Sorting 39 | 14 | Chr 2, 3 and 5: 3 each / Chr 4, 11, 13, 14 and 22:1 each | ACTN1/ ARRB1/ GRM7/ SEZ6L |
| Total | 648 |