Table 2. Knockdown of HDR genes results in abnormal morphology in C. elegans oocytes.
RNAi | Dose Gy | Average chromosomes per oocyte | Normal oocytes (%) | Clustered oocytes (%) | Total oocytes examined |
---|---|---|---|---|---|
control | 0 | 5.8 | 107 (100) | 0 | 107 |
120 | 5.7 | 86 (100) | 0 | 86 | |
mre-11 | 0 | 10.5 | 63 (100) | 0 | 63 |
120 | 7.1 | 23 (43.4) | 30 (56.6) | 53 | |
rad-51 | 0 | 5.5 | 49 (96.0) | 2 (3.9) | 51 |
120 | 5.5 | 31(54.4) | 26 (45.6) | 57 | |
lig-4 | 0 | 5.7 | 67 (100) | 0 | 67 |
120 | 5.6 | 40 (100) | 0 | 40 | |
cku-80 | 0 | 5.8 | 80 (97.6) | 2 (2.4) | 82 |
120 | 5.6 | 24 (96.0) | 1 (4.0) | 25 |
15–25 animals were examined per group at each dose