Table 3.
Comparison of demographics, clinical characteristics and health utilization among among children ages 8 to 20 with a diagnosis of familial hypercholesterolemia (FH) or other dyslipidemia by use of lipid lowering therapy (n=2,148)
| Lipid Lowering Therapy Initiation (Cases) (N=182) | Controls (N=1,966) | Odds Ratio | (95% CI) | P-value | |||
|---|---|---|---|---|---|---|---|
|
|
|||||||
| n | % | n | % | ||||
| Age ≥ 15 years | 124 | 68.13 | 1,377 | 63.96 | 0.9 | (0.7–1.3) | 0.68 |
| Male | 121 | 66.48 | 1,010 | 46.91 | 1.9 | (1.4–2.6) | 0.00 |
| CVD Risk Factors | |||||||
| Diabetes Type I | 5 | 2.75 | 76 | 3.53 | 0.7 | (0.2–1.8) | 0.61 |
| Diabetes Type II | 2 | 1.10 | 124 | 5.76 | 0.2 | (0.0–0.6) | 0.00 |
| Hypertension | 9 | 4.95 | 148 | 6.87 | 0.6 | (0.3–1.3) | 0.26 |
| Obesity | 7 | 3.85 | 175 | 8.13 | 0.4 | (0.2–0.9) | 0.02 |
| Additional Indications for LLT | |||||||
| Congenital Heart Disease | 1 | 0.55 | 6 | 0.28 | 1.8 | (0.0–15.0) | 0.92 |
| Chronic Kidney Disease | 1 | 0.55 | 16 | 0.74 | 0.7 | (0.0–4.4) | 1.00 |
| Kawasaki Disease | 0 | 0.00 | 0 | 0.00 | N/A | N/A | N/A |
| Heart transplant | 0 | 0.00 | 0 | 0.00 | N/A | N/A | N/A |
| Chronic Inflammatory Disease | 0 | 0.00 | 11 | 0.51 | N/A | N/A | N/A |
| Health Utilization 1 | |||||||
| Inpatient stay | 7 | 3.85 | 142 | 6.60 | 0.7 | (0.5–1.0) | 0.04 |
| Outpatient visit | 81 | 44.51 | 1,037 | 48.17 | 0.5 | (0.2–1.1) | 0.10 |
| Prescription Medication | 15 | 8.24 | 1,027 | 47.70 | 0.1 | (0.0–0.1) | 0.00 |
CI= confidence interval;
1
>1 inpatient visit in past year ≥ 5 outpatient visits ≥2 prescription drug dispensings in the last 12 months