Table 1.
Control | Diabetes | |
---|---|---|
N | 8 | 19 |
Plasma glucose (mmol/L) | 11.6 (9.8–13.1) | 21.5 (18.1–27.8)a |
Body weight at start (g) | 25.5 (24.7–26.9) | 26.0 (24.9–27.0) |
Body weight at termination (g) | 25.6 (24.7–27.9) | 22.1 (21.1–23.2)a |
Kidney weight (mg) | 150 (141–160) | 139 (128–148)a |
Kidney weight/body weight (mg/g) | 5.7 (5.4–5.9) | 6.3 (5.9–6.7)a |
GFR (mL kg−1 min−1; inulin) | 10.5 (8.4–12.4) | 7.7 (6.3–9.4)a |
AER (μg/24 h) | 135 (77–158) | 400 (242–544)a |
Plasma CTGF (pmol/l) | 230 (185–295) | 340 (290–370)a |
Urinary CTGF (fmol/24 h) | ≤57 | 999 (190–2946)a |
Data are median (interquartile range); a P < 0.05 versus control mice in Mann-Whitney U test.