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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Adv Drug Deliv Rev. 2014 Dec 29;88:123–137. doi: 10.1016/j.addr.2014.12.006

Figure 4.

Figure 4

Micro-CT sections following implantation of PGS scaffolds without BMSCs (PGS), or seeded with BMSCs transfected with lentiviruses encoding for miR-31 overexpression (BMSCs/miR-31), miR-31 inhibition (BMSCs/anti-miR), or an irrelevant DNA sequence (BMSCs/miR-Neg). These data suggest that miR-31 impairs bone repair, while transfection of BMSCs with anti-miR-31 prior to implantation greatly increases bone regeneration. Reproduced with kind permission from eCM journal (www.ecmjournal.org).