Skip to main content
. Author manuscript; available in PMC: 2015 Jun 30.
Published in final edited form as: Sci Signal. 2014 Aug 12;7(338):ra75. doi: 10.1126/scisignal.2005196

Fig. 7. Schematic illustrating aPKC-containing signaling complexes in cell-autonomous RTK and non–cell-autonomous TNFα–NF-κB oncogenic signaling in glioblastoma.

Fig. 7

EGFR and/or other oncogenic RTK signaling pathways within the glioblastoma cell activate aPKC in a Par6-dependent fashion and lead to the expression of oncogenic genes. In parallel, TNFα produced by macrophages in the tumor microenvironment activates aPKC in a p62-dependent manner. This activation leads to the expression of NF-κB–dependent genes, which function as EGFR-independent oncogenic signals in glioblastoma.