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. 2015 Jun 18;58(6):911–924. doi: 10.1016/j.molcel.2015.06.012

Figure 4.

Figure 4

ADP-Ribosylation Tags

(A) Poly(ADP-ribose) can be simplified to mono(ADP-ribose) as in (B) by the glycohydrolase activity of PARG/ARH3, (C) to phosphoribose through digestion by phosphodiesterase, or (D) to a hydroxamic acid derivative though exposure to hydroxylamine. Of note, hydroxylamine treatment on ADP-ribosylated arginine results in the formation of the hydroxyamate of ADP-ribose (Moss et al., 1983) and therefore will likely not leave the 15.01 Da signature on formerly modified arginine residues as in glutamate/aspartate residues (Zhang et al., 2013). A representative acidic attachment site (red) is used for illustration.