Table 3. Transmission of human prions to transgenic mice homozygous for human PrP V127.
| Inoculum |
Transmission data |
|||||
|---|---|---|---|---|---|---|
| Aetiology | Source Code | Human PrPSc type* | Attack rate† | Incubation period, (days p.i) | Attack rate† | Incubation period, (days p.i) |
|
Tg183
V127M129/V127M129 |
Tg190
V127M129/V127M129 |
|||||
| kuru | I516 | T3 VV | 0/19 | >488-604 | 0/22 | >391-609 |
| kuru | I520 | T3 VV | 0/19 | >391-609 | 0/19 | >370-609 |
| kuru | I10336 | T3 MV | 0/21 | >405-607 | 0/24 | >463-617 |
| kuru | I518 | T2 MM | 0/12 | >439-600 | 0/13 | >432-603 |
| vCJD | I342 | T4 MM | 0/8 | >553-605 | 0/10 | >506-604 |
| vCJD | I7042 | T4 MM | 0/11 | >522-609 | 0/14 | >446-607 |
| iCJD (GH) | I035 | T1 MM | 0/10 | >434-622 | 0/10 | >450-602 |
| sCJD | I11058 | T1 MM | 0/8 | >411-609 | 0/9 | >454-612 |
| iCJD (DM) | I026 | T2 MM | 0/9 | >381-602 | 0/8 | >516-602 |
| sCJD | I7040 | T2 MM | 0/8 | >524-601 | 0/6 | >564-600 |
| sCJD | I280 | T2 VV | 0/9 | >532-602 | 0/9 | >425-601 |
| sCJD | I278 | T2 VV | 0/7 | >530-602 | 0/7 | >417-601 |
| sCJD | I284 | T2 MV | 0/6 | >549-603 | 0/6 | >466-609 |
| sCJD | I1478 | T2 MV | 0/7 | >517-602 | 0/7 | >418-617 |
| sCJD | I7394 | T3 VV | 0/8 | >500-600 | 0/8 | >600-603 |
| sCJD | I764 | T3 MV | 0/10 | >447-602 | 0/8 | >484-607 |
| iCJD (GH) | I2651 | T3 VV | 0/7 | >563-606 | 0/7 | >487-599 |
| iCJD (GH) | I020 | T3 MV | 0/6 | >546-603 | 0/6 | >572-600 |
(days p.i), days post inoculation; vCJD, variant CJD; sCJD, sporadic CJD; iCJD, iatrogenic CJD; GH, growth hormone; DM, dura mater
*
According to classification of Hill et al.28
†
Attack rate is defined as the total of clinically affected and sub-clinically infected mice as a proportion of the number of inoculated mice. Sub-clinical prion infection was assessed by immunoblotting and/or immunohistochemical examination of brain. As no clinical transmission of prion disease was observed the interval between inoculation and death (from either senescence, culling due to inter-current illness or termination of the experiment) is reported as >x-y days.