Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 11;14:81. doi: 10.1186/s12943-015-0353-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Yao et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Cytogenetic and fluorescence in situ hybridization analyses of the patient. The bone marrow cells were cultured for 24 h and were analyzed for karyotyping and fluorescence in situ hybridization (FISH) with standard procedures. Clonal karyotypic abnormalities were described according to the International System for Human Cytogenetic Nomenclature (ISCN, 2009). A) Karyotype was analyzed on R-banded metaphases showing a t(5;21)(q21;q22), suggesting the involvement of the RUNX1 gene located at 21q22. B) FISH analysis of the rearrangement of RUNX1 by using BAC probes RP11-177 L11 (red) and RP11-77I17 (green).The separated red and green signals indicated a translocation involving RUNX1 gene.