Comparison of the diagnostic value among autoantibodies to CENPF, AFP and combined autoantibody to CENPF and AFP for HCC or early HCC. Upper panel: ROC curve for autoantibodies to CENPF, AFP and combined autoantibody to CENPF and AFP to distinguish HCC (A) or early HCC (B) from controls (LC + CH + HC). Lower panel: comparison of positivity for the autoantibodies to CENPF, AFP and combined autoantibody to CENPF and AFP in HCC (C) or early-HCC (D). ROC, receiver operating characteristic. HCC, hepatocellular carcinoma; LC, liver cirrhosis; CH, chronic hepatitis; HC, healthy controls; aAb: autoantibody.