Table 1.
Clinical characteristics of research subjects for SERPA analysis and microarray detection.
| Variables | SERPA analysis (n = 30) |
Microarray detection (n = 914) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| HCC (n = 10) |
Liver cirrhosis (n = 10) |
Healthy control (n = 10) |
HCC (n = 295) |
Liver cirrhosis (n = 132) |
Chronic hepatitis (n = 119) |
Non-liver cancers (n = 103) |
Healthy controls (n = 265) |
||
| AFP (ng/ml) | < 20 | 6 | 8 | 10 | 122 | 116 | 101 | 101 | 265 |
| 20–400 | 4 | 2 | 0 | 119 | 15 | 17 | 2 | 0 | |
| > 400 | 0 | 0 | 0 | 54 | 1 | 1 | 0 | 0 | |
| Age (years) | Range | 43–65 | 36–62 | 28–60 | 24–88 | 31–76 | 25–66 | 25–90 | 20–66 |
| (Mean) | (52.6) | (48.3) | (43.5) | (56.3) | (50.2) | (43.2) | (64.0) | (45.8) | |
| Gender | Male | 7 | 7 | 7 | 239 | 101 | 96 | 58 | 166 |
| Female | 3 | 3 | 3 | 56 | 31 | 23 | 45 | 99 | |
| HBV/HCV infection | HBV + | 10 | 10 | 0 | 260 | 108 | 96 | 1 | 0 |
| HCV + | 0 | 0 | 0 | 17 | 15 | 13 | 2 | 0 | |
| HBV −/HCV − | 0 | 0 | 10 | 18 | 9a | 10a | 89b | 265 | |
| HBsAg | Positive | 10 | 10 | 0 | 260 | 108 | 96 | 1 | 0 |
| Negative | 0 | 0 | 10 | 35 | 24 | 23 | 91b | 265 | |
| ALT (U/L) | ≤ 75 | 8 | 8 | 10 | 255 | 107 | 89 | – | 265 |
| > 75 | 2 | 2 | 0 | 40 | 25 | 30 | – | 0 | |
| Child-Pugh | A | 8 | 8 | – | 239 | 81 | – | – | – |
| B | 2 | 2 | – | 42 | 37 | – | – | – | |
| C | 0 | 0 | – | 14 | 11 | – | – | – | |
| Missing | 0 | 0 | – | 0 | 3 | – | – | – | |
| BCLC stage | A | 10 | – | – | 106 | – | – | – | – |
| B | 0 | – | – | 135 | – | – | – | – | |
| C | 0 | – | – | 39 | – | – | – | – | |
| D | 0 | – | – | 15 | – | – | – | – | |
| Tumor differentiation | Well | 4 | – | – | 32 | – | – | – | – |
| Moderate | 6 | – | – | 77 | – | – | – | – | |
| Poor | 0 | – | – | 37 | – | – | – | – | |
| Missing | 0 | – | – | 149 | – | – | – | – | |
| Tumor size (cm) | ≤ 5 | 10 | – | – | 109 | – | – | – | – |
| > 5 | 0 | – | – | 184 | – | – | – | – | |
| Missing | 0 | – | – | 2 | – | – | – | – | |
| Vascular invasion/metastasis | Yes | 0 | – | – | 46 | – | – | – | – |
| No | 10 | – | – | 247 | – | – | – | – | |
| Missing | 0 | – | – | 2 | – | – | – | – | |
HCC, hepatocellular carcinoma; BCLC: Barcelona Clinic Liver Cancer staging system; HBV +: with HBV infection; HCV +: with HCV infection; HBV −/HCV −: without HBV and HCV infection. SERPA: serological proteome analysis. –: data not available.
a
Alcoholic.
b
11 non-liver cancer cases miss the data of HBV/HCV infection.