Extended Data Figure 6. The brain images show regions that predict binge drinking at age 16 from data collected at age 14.

The bar charts show the contribution of each brain metric to the prediction accuracy of the shown clusters, which were derived from the training data. a, b, Future binge drinkers had reduced activation during reward anticipation in occipito-temporal and posterior cingulate regions (a) and for reward outcomes had reduced activity in the left temporal pole but increased activity in bilateral superior frontal gyrus (b). c, When failing to inhibit a motor response, future binge drinkers showed greater activity in the right middle, medial and precentral gyri and in the left postcentral and middle frontal gyri. d, e, Future binge drinkers showed reduced activity in the left middle frontal gyrus when processing angry faces (d) and also had reduced grey matter volume in the right parahippocampal gyrus but increased grey matter volumes in the left postcentral gyrus (e).