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. 2015 Jul;100(7):914–926. doi: 10.3324/haematol.2014.113092

Figure 5.

Figure 5.

Cytotoxic killing of AML cells by expanded huNK cells and CSL362 in ADCC assays. (A) Cell lysis of AML cells mediated by huNK cells harvested from ex vivo expansions, with 10 μg/mL of CSL362 or IgG1 control. Each dot represents an experiment conducted with an independent huNK donor (triplicates were performed per experiment). Background AML cell death was subtracted from all values. Horizontal lines represent the median. *P<0.05; ***P<0.001; and n.s.: non-significant. (B) Summary of % cell lysis in ADCC assays with or without CSL362 against AML xenografts with expanded NK cells from different donors, without correction for background AML cell death. Specific lysis refers to the ADCC mediated specifically by the addition of CSL362.