Fig. 2.

Model for human SLC25A4. A homology model was built, employing the crystal structure of the mitochondrial ADP/ATP carrier (PDB accession file 1OKC.pdb, sequence identity 96%) with the molecular modeling package ICM Pro (Molsoft, Inc, La Jolla, USA) and was next optimized and minimized following standard parameters. Alpha-helices are depicted in red, other areas in gray. Location of mutated proline (yellow) in SLC25A4 protein is situated in the membrane