Table 3.
Interaction analysis between the variations of NFκB1 and IκBα on NPC risk.
|
Cases (n = 1590) IκBα: rs696 G>A |
Controls (n = 1979) IκBα: rs696 G>A |
Crude OR (95% CI)a |
Adjusted OR (95% CI)a |
P inter b | |||
|---|---|---|---|---|---|---|---|
| GG + AG n (%) |
AA n (%) |
GG + AG n (%) |
AA n (%) |
AA versus GG + AG | AA versus GG + AG | ||
| NFκB1: | |||||||
| rs28362491 del/ins | |||||||
| del/del | 204 (75.8) | 65 (24.2) | 331 (79.0) | 88 (21.0) | 1.20 (0.83–1.73) | 1.24 (0.85–1.80) | |
| del/ins | 575 (74.8) | 194 (25.2) | 762 (80.2) | 188 (19.8) | 1.37 (1.09–1.72) | 1.38 (1.09–1.74) | |
| ins/ins | 392 (71.0) | 160 (29.0) | 482 (79.0) | 124 (21.0) | 1.54 (1.18–2.01) | 1.53 (1.17–2.02) | |
| Combined genotypes | 2.25 × 10−6 | ||||||
| del/ins + ins/ins | 967 (73.2) | 354 (26.8) | 1244 (79.7) | 316 (20.3) | 1.44 (1.21–1.71) | 1.45 (1.22–1.74) | |
aORs were adjusted for age, sex and smoking status, and alcohol use, family history of cancer in a logistic regression model.
b P value of test for the multiplicative interaction between rs696 G>A genotypes and rs28362491 del/ins genotypes on cancer risk in logistic regression models.