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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Biol Chem. 2006 Apr 10;281(24):16377–16383. doi: 10.1074/jbc.M509995200

FIGURE 5. Model showing how CF may regulate glucose-6-phosphatase, glucose, and group size.

FIGURE 5

Our working hypothesis is that when CF binds to its surface receptor, this signal inhibits an unknown cytosolic protein. In the absence of CF this protein increases glucose-6-phosphatase activity by decreasing the Km to produce more glucose. A protein found in wild-type cytosol that affects glucose-6-phosphatase may be the same cytosolic protein or may be a different protein. Glucose inhibits cell motility and increases cell-cell adhesion to increase group size. ER, endoplasmic reticulum.