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. 2015 Jun 30;8:34. doi: 10.1186/s12920-015-0106-0

Fig. 2.

Fig. 2

Enrichment analysis of biologically modulated pathways. Analysis first shows a significant enrichment in TGFbeta signaling modulated by SMAD proteins: as the majority of genes are down-regulated, we have inhibition of this pathway in Saos clones, with an effect that increases over time. Other important and significantly modulated are the EMT and Apoptotic pathways. (min (p-value) = most significant p-value among the 3 time points after multiple correction test)