Figure 3. Reduced survival of CXCR7^ΔEND/ΔEND mice with orthotopic tumor implants of E0771-FL breast cancer cells.

A) We measured tumor growth in mice with orthotopic implants of E0771-FL cells by bioluminescence imaging at indicated days. Graph shows mean values + SEM for photon flux in CXCR7^ΔEND/ΔEND and control mice (n = 8 mice per group). Arrow designates when tumor implants were resected on day 21. B) Following resection of orthotopic tumor implants, we monitored CXCR7^ΔEND/ΔEND and control mice until each animal had to be euthanized for humane end points. Mice surviving through 50 days had no detectable tumor as assessed by palpation of mammary fat pads and bioluminescence imaging. *, p < 0.05.