Fig 2.

Treatment schema for patients in Radiation Therapy Oncology Group RTOG-0630 (A Phase II Trial of Image-Guided Preoperative Radiotherapy for Primary Soft Tissue Sarcomas of the Extremity). Chemotherapy was allowed at the discretion of the treating medical oncologist for deep (≥ 8 cm) sarcomas in maximum dimension with intermediate- to high-grade histology (grade 3 or 4; American Joint Committee on Cancer, 6th edition). Treating centers were certified by the RTOG for sarcoma image-guided radiation therapy (RT) as well as for 3-dimensional conformal radiation therapy (3D-CRT) and/or intensity-modulated RT (IMRT). Radiation therapy technique (3DCRT v IMRT) was at the discretion of the treating radiation oncologist. CT, computed tomography; EBRT, external beam RT; HDR, high-dose rate; IORT, intraoperative RT; LDR, low-dose rate; MRI, magnetic resonance imaging.