Table 2.
Patient and Tumor Characteristics for Cohort B of RTOG-0630 (n = 79)
| Characteristic | No. | % | Tumor Size (cm) |
|||
|---|---|---|---|---|---|---|
| < 8 | % | ≥ 8 | % | |||
| Age, years | ||||||
| Median | 61 | |||||
| Range | 24-88 | |||||
| Sex | ||||||
| Male | 42 | 53.2 | ||||
| Female | 37 | 46.8 | ||||
| Race/ethnicity | ||||||
| American Indian or Alaskan native | 1 | 1.3 | ||||
| Black or African American | 4 | 5.1 | ||||
| White | 71 | 89.9 | ||||
| More than one race | 1 | 1.3 | ||||
| Unknown | 2 | 2.5 | ||||
| Zubrod performance status | ||||||
| 0 | 61 | 77.2 | ||||
| 1 | 18 | 22.8 | ||||
| Histology (study chair review) | ||||||
| Extraskeletal myxoid chondrosarcoma | 1 | 1.3 | ||||
| Leiomysarcoma | 6 | 7.6 | ||||
| Epitheliod | 1 | 1.3 | ||||
| Pleomorphic | 1 | 1.3 | ||||
| Liposarcoma | ||||||
| Dedifferentiated | 1 | 1.3 | ||||
| Myxoid | 10 | 12.7 | ||||
| Myxoid/round cell | 3 | 3.8 | ||||
| Pleomorphic | 1 | 1.3 | ||||
| Well differentiated | 2 | 2.5 | ||||
| Low-grade fibromyxoid sarcoma | 1 | 1.3 | ||||
| Malignant peripheral nerve sheath tumor, spindle cell | 1 | 1.3 | ||||
| Myxofibrosarcoma | 17 | 21.5 | ||||
| Pleomorphic rhabdomyosarcoma | 1 | 1.3 | ||||
| Sclerosing epithelioid fibrosarcoma | 1 | 1.3 | ||||
| Synovial sarcoma | ||||||
| Biphasic | 1 | 1.3 | ||||
| Monophasic spindle cell | 3 | 3.8 | ||||
| Unclassified | 3 | 3.8 | ||||
| Undifferentiated pleomorphic sarcoma | 18 | 22.8 | ||||
| Unknown | 7 | 8.9 | ||||
| Disease location | ||||||
| Upper extremity | 11 | 13.9 | ||||
| Shoulder | 2 | 2.5 | ||||
| Proximal arm | 5 | 6.3 | ||||
| Distal arm | 2 | 2.5 | ||||
| Proximal forearm | 1 | 1.3 | ||||
| Distal forearm | 1 | 1.3 | ||||
| Lower extremity | 62 | 78.5 | ||||
| Proximal thigh | 33 | 41.8 | ||||
| Distal thigh | 13 | 16.5 | ||||
| Proximal leg | 10 | 12.7 | ||||
| Distal leg | 6 | 7.6 | ||||
| Hip | 2 | 2.5 | ||||
| Buttocks | 4 | 5.1 | ||||
| Disease size (longest diameter, cm) | ||||||
| Median | 10.5 | |||||
| Range | 3.5-30 | |||||
| T stage | ||||||
| T1a | 4 | 5.1 | ||||
| T1b | 5 | 6.3 | ||||
| T2a | 10 | 12.7 | ||||
| T2b | 60 | 75.9 | ||||
| Histologic grade (central review) | ||||||
| G1 | 13 | 16.5 | 2 | 2.5 | 11 | 13.9 |
| G2 | 21 | 26.6 | 7 | 8.9 | 14 | 17.7 |
| G3 | 38 | 48.1 | 14 | 17.7 | 24 | 30.4 |
| Unknown | 7 | 8.9 | 2 | 2.5 | 5 | 6.3 |
| Biopsy type (central review) | ||||||
| Core needle | 62 | 78.5 | ||||
| Incisional | 8 | 10.1 | ||||
| Excisional | 1 | 1.3 | ||||
| Unknown | 8 | 10.1 | ||||
Abbreviation: RTOG-0630, Radiation Therapy Oncology Group RTOG-0630 (A Phase II Trial of Image-Guided Preoperative Radiotherapy for Primary Soft Tissue Sarcomas of the Extremity) trial.