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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Biomater Sci. 2015 Mar 3;3(7):894–907. doi: 10.1039/C5BM00006H

Figure 1.

Figure 1

Several methods have been developed to control the shape of polymeric nanoparticles for therapeutic delivery applications. (A) PRINT technology allows for the generation of particles with controlled shapes and surface chemistries through harvesting from polymer molds with low surface energy;14 (reprinted with permission, ©2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim) (B) Two distinct methods for generating nanoparticles with nonspherical shapes through stretching and liquefication of precursor films, leading to the formation of rod shaped and barrel shaped particles;32 (©2007 National Academy of Sciences, USA) (C) Self-assembly of PEG-polycation/DNA nanoparticles in solutions with varying solvent polarity leads to the formation of different shapes, including spheres, rod-like, and worm-like particles.125 (reprinted with permission, ©2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)