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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: J Neurochem. 2010 Apr 19;114(1):281–290. doi: 10.1111/j.1471-4159.2010.06761.x

Fig. 1.

Fig. 1

Effects of antagonists of mGluR1 (A,B) and mGluR5 (C,D), and agonists of group II (E,F) and group III (G,H) mGluRs on nociceptive responses (nociceptive score +/− standard error of the mean (SEM)) to formalin in both sham (left column) and CCI (right column) rats. The mGluR agents reduce formalin-induced nociception to varying degrees in both sham and CCI rats. Asterisks indicate the time points where nociceptive scores are significantly reduced by the drug as compared to vehicle (*p < 0.05, Fisher’s LSD post hoc).