Table 2.

Estimated annual human and economic burden of major adult vaccine-preventable disease in the United States, 2013, for adults aged, a 50 and Older, b 65 and Older

Disease	Est. cases	Est. medical cost (per case)	Est. indirect cost (per case)a	Est. total cost (per case)	Est. total medical cost (in millions)	Est. total indirect cost (in millions)	Est. total cost (in millions)
a
Influenzab,c	8101,104	$1571	$404	$1976	$12,729.3	$3275.3	$16,004.6
Pneumococcald	603,337				$4618.1	$446.5	$5064.7
Bacteremiad	32,041	$27,829	$1568	$29,397	$891.7	$50.2	$941.9
Meningitisd	2037	$33,692	$1560	$35,252	$68.6	$3.2	$71.8
NPP (inpatient)d	223,288	$15,335	$885	$16,220	$3424.2	$197.6	$3621.8
NPP (outpatient)d	345,972	$676	$565	$1241	$233.7	$195.5	$429.2
Herpes zostere,f,g	937,773	$1974	$3408	$5382	$1851.0	$3195.9	$5046.9
Pertussish,i	387,809	$432	$593	$1026	$167.6	$230.1	$397.7
Total	10,030,023				$19,366.1	$7147.7	$26,513.8
b
Influenzab,c	4019,759	$1867	$201	$2068	$7503.3	$809.5	$8312.8
Pneumococcald	440,187				$3572.2	$214.9	$3787.1
Bacteremiad	19,960	$25,181	$879	$26,060	$502.6	$17.6	$520.2
Meningitisd	1278	$32,803	$879	$33,682	$41.9	$1.1	$43.0
NPP (inpatient)d	187,982	$15,221	$641	$15,862	2861.3	$120.4	$2981.7
NPP (outpatient)d	230,968	$721	$328	$1049	$166.4	$75.8	$242.2
Herpes zostere,f,g	555,989	$2354	$3074	$5427	$1308.5	$1708.9	$3017.4
Pertussish,i	207,241	$432	$593	$1026	$89.6	$122.9	$212.5
Total	5223,176				$12,473.7	$2856.2	$15,329.9

All costs were adjusted to 2013 U.S. dollars. NPP is non-bacteremic pneumococcal pneumonia caused by S. pneumoniae. ‘NPP inpatient’ refers to cases of NPP that require hospitalization where as ‘NPP outpatient’ refers to cases of NPP that do not require hospitalization

^a(Grosse et al., 2009)

^b(Molinari et al., 2007)

^c(Turner et al., 2006)

^d(Weycker et al., 2012)

^e(Tseng et al., 2011)

^f(Yawn et al., 2007)

^g(Singhal et al., 2011)

^h(Masseria & Krishnarajah, 2013)

ⁱ(Lee et al., 2004)