Table 1.
Patients’ characteristics at presentation
| Parameter | All n = 75 | PR3-ANCA n = 18 | MPO-ANCA n = 57 | P value |
|---|---|---|---|---|
| General | ||||
| Gender (% Male) | 48 | 78 | 39 | 0.004 |
| Age >65 years (%) | 35 | 11 | 42 | 0.02 |
| Age (years) | 60 [53; 68] | 58.0 [43; 62] | 63 [55; 69] | 0.01 |
| Cold season at diagnosis | 60 % | 65 % | 62 % | 0.81 |
| Time to diagnosis (mo) | 2.0 [1.0; 5.6] | 1.5 [1.0; 3.0] | 2.0 [1.0; 6.0] | 0.12 |
| Vasculitis symptoms | ||||
| Constitutional (%) | 84 | 94 | 81 | 0.17 |
| Skin (%) | 9 | 17 | 7 | 0.22 |
| Ocular (%) | 3 | 11 | 0 | 0.01 |
| Upper respiratory (%) | 8 | 22 | 4 | 0.01 |
| Lung (%) | 48 | 50 | 47 | 0.85 |
| Severe lung hemorrhage | 31 % | 39 % | 28 % | 0.39 |
| Kidney (%) | 100 | 100 | 100 | 1.00 |
| Digestive (%) | 4 | 0 | 5 | 0.32 |
| CNS (%) | 4 | 0 | 5 | 0.32 |
| Organs affected (No) | 2 [1; 2] | 2 [1; 3] | 2 [1; 2] | 0.08 |
| BVAS | 17 [15; 21] | 21 [15; 22] | 17 [15; 20] | 0.05 |
| Inflammation | ||||
| Hemoglobin (g/dL) | 8.5 [7.5; 9.8] | 7.7 [5.7; 9.5] | 9.0 [7.8; 9.8] | 0.04 |
| Severe anemia (%) | 35 | 56 | 28 | 0.03 |
| WBC (per mm3) | 9750 [7800; 14400] | 10700 [7800; 15075] | 9650 [7683; 13900] | 0.64 |
| ESR (mm/1 h) | 97 [64; 120] | 100 [80; 140] | 94 [63; 120] | 0.18 |
| Fibrinogen (mg/dL) | 680 [568; 800] | 714 [608; 806] | 670 [547; 800] | 0.48 |
| Serum albumin (mg/dL) | 3.6 [3.10; 4.0] | 3.3 [2.9; 3.7] | 3.7 [3.1; 4.0] | 0.15 |
| Kidney disease | ||||
| Histopathologic class | ||||
| Crescentic (%) | 52 | 67 | 47 | 0.52 |
| Focal (%) | 5 | 6 | 5 | |
| Mixed (%) | 32 | 22 | 35 | |
| Sclerotic (%) | 11 | 6 | 12 | |
| Creatinine (mg/dL) | 5.0 [3.4; 7.9] | 7.2 [4.2; 10.0] | 4.8 [3.1; 7.2] | 0.04 |
| Proteinuria (g/day) | 0.8 [0.5; 2.2] | 1.0 [0.4; 1.4] | 0.8 [0.5; 2.3] | 0.73 |
| Hematuria (per mm3) | 260 [190; 800] | 535 [288; 1200] | 230 [183; 623] | 0.005 |
| Macroscopic hematuria | 44 % | 78 % | 33 % | 0.001 |
| RBC casts (%) | 37 | 72 | 28 | 0.02 |
| Dialysis at presentation | 27 % | 50 % | 19 % | 0.01 |
Values are median [quartile 1; quartile 3] if not otherwise specified
mo months, CNS Central nervous system, No number, BVAS Birmingham Vasculitis Activity Score, WBC white blood cells, ESR erythrocyte sedimentation rate, RBC red blood cells