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. 2015 Jun 1;28(5):255–264. doi: 10.1089/vim.2015.0005

FIG. 4.

FIG. 4.

CD8+ T cell isolated from the lungs of MCMV/CY mice have increased MCMV-specific effector function during pneumonitis, and higher absolute numbers of intralung effector CD8+ T lymphocytes. (A) and (B) Representative ICCS for IFN-γ, and granzyme B in MCMV and MCMV/CY mice on day 14 CD8+ T cells with medium or ex vivo pp89 restimulation. Quadrant values represent detected frequencies of each population, gating on CD8+ T cells from the lung or spleen, respectively. (C) and (D) Mean numbers of CD8+ cells secreting IFN-γ by ICS upon ex vivo pp89 restimulation on days 7, 14, and 21 from the lung or spleen of MCMV/CY and MCMV mice. Data points represent mean values±SEM from each treatment group, with p-values determined by t-test. Results represent minimum three separate experiments with individual responses from 8–10 mice per group. *p<0.05.