Table II.
Hemodynamics, Pulmonary Artery Hypertension, and Impaired Respiratory Function in a Lamb Model of Pediatric Lung Failure
| Intraoperative | Postoperative | P - values | |||||
|---|---|---|---|---|---|---|---|
| Baseline | Ligation | Overall Duration |
Final End-Point |
Baseline vs. Ligation |
Baseline vs. Duration |
Baseline vs. End-Point |
|
| n = 7 | n = 7 | n = 7 | n = 7 | ||||
|
mPPA (mmHg) |
17.4 ± 2.20 | 28.5 ± 5.20 | 28.6 ± 2.20 | 29.4 ± 5.30 | < 0.001 | 0.001 | 0.001 |
|
mPART
(mmHg) |
79.4 ± 18.7 | 80.5 ± 14.5 | 76.6 ± 9.90 | 72.0 ± 11.0 | 0.899 | 0.772 | 0.485 |
|
CO
(L/min) |
4.12 ± 1.41 | 3.93 ± 0.90 | 3.79 ± 1.72 | 3.62 ± 1.43 | 0.727 | 0.885 | 1.000 |
| pH | 7.42 ± 0.11 | 7.30 ± 0.12 | 7.21 ± 0.17 | 7.20 ± 0.12 | 0.038 | 0.046 | 0.033 |
|
PaCO2
(mmHg) |
40.4 ± 9.30 | 57.3 ± 12.7 | 56.4 ± 16.5 | 61.1 ± 16.9 | 0.026 | 0.042 | 0.099 |
|
PaO2
(mmHg) |
378 ± 27.8 | 356 ± 49.6 | 111 ± 16.3 | 107 ± 14.9 | 0.327 | < 0.001 | < 0.001 |
|
Vd/Vt
(%) |
48.6 ± 5.70 | 60.1 ± 5.20 | Not Measured | 0.012 | -- | -- | |
|
RR
(min−1) |
15 ± 0 (MV support) | 63.3 ± 21.0 | 71.5 ± 34.9 | -- | -- | -- | |
|
Sup. O2
(L/min) |
1.1 ± 0.9 | 5.3 ± 4.1 | -- | -- | -- | ||
Values are expressed as means ± SD. mPART, mean arterial pressure; mPPA, mean pulmonary arterial pressure; CO, cardiac output; PaCO2, arterial partial pressure of carbon dioxide; PaO2, arterial partial pressure of oxygen; Vd/Vt, dead space fraction; RR, respiratory rate; Sup O2, supplemental oxygen; MV, mechanical ventilation.