Table 4.

Morphine response outcomes by SOAPP-R clinical cutoff status.

	Clinical Cutoff Status
Morphine Response Outcomes	SOAPP-R <18 (n=41)	SOAPP-R ≥ 18 (n=14)
DELTA Drug Effect	1.4±1.10	1.4±1.34
DELTA Drug Liking	3.8±23.87	19.3±20.53*
DELTA Take Again	3.4±23.88	35.9±26.79***
VAS Feeling High	34.0±32.04	40.1±34.25
VAS Feeling Sedated	22.9±32.42	45.0±29.42*
VAS Feeling Elated	14.9±31.63	27.0±33.31
VAS Feeling Down	4.8±16.90	−5.2±27.80
VAS Feeling Anxious	7.1±19.72	1.0±29.32
VAS Feeling Good	7.0±31.79	23.1±32.16
VAS Feeling Bad	8.6±27.33	−11.4±32.07*
Morphine Effect on Acute Ischemic Pain -
MPQ-Sensory	−1.4±6.00	−2.7±6.06
MPQ-Affective	−0.6±1.84	−1.1±2.38
Tolerance	27.3±111.97	70.3±160.17
Morphine Effect on Acute Thermal Pain -
MPQ-Sensory	−0.4±4.69	−3.1±5.71†
MPQ-Affective	0.0±1.17	−0.9±3.01
Tolerance	0.3±1.00	0.0±0.76
Morphine Effect on Chronic Pain -
MPQ-Sensory	−0.7±3.75	−4.8±7.05**
MPQ-Affective	0.2±1.75	−0.6±1.45

^†p<.10

^*p<.05

^**p<.01

^***p<.001

Note: Clinical cutoff of 18 or higher on the SOAPP-R for identifying increased opioid risk in chronic pain patients is based on recommendations of Butler et al.^9,10. DELTA, VAS opioid effects, and pain morphine response outcomes all reflect differences between morphine and placebo condition responses.