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Effect of PUMA-specific siRNA on Tau-induced apoptosis of HepG2 cells. Apoptotic cells of HepG2 were analyzed by flow cytometry. A, control; B, NC; C, si-PUMA; D, si-PUMA + Tau and E, Tau group. Data from triplicate experiments were collected on a histogram (n=4). **P<0.01, vs. control; ##P<0.01, vs. si-PUMA group. FITC, fluorescein isothiocyanate; PUMA, p53 upregulated modulator of apoptosis; Tau, taurine; PI, propidium iodide; NC, negative control; si, small interfering.
