Table II.
Meta-analysis of the rs531564 polymorphism with the cancer risk.
| Test of association | Test of heterogeneity | |||||
|---|---|---|---|---|---|---|
| Study groups | OR (95% CI) | Z | P-value | Model | Ph | I2, % |
| Overall | ||||||
| G vs. C | 0.86 (0.77–0.96) | 2.68 | 0.007 | F | 0.23 | 28 |
| GG vs. CC | 0.52 (0.34–0.79) | 3.10 | 0.002 | F | 0.38 | 4 |
| CG vs. CC | 0.86 (0.67–1.10) | 1.24 | 0.220 | R | 0.03 | 62 |
| GG/CG vs. CC | 0.84 (0.67–1.03) | 1.65 | 0.100 | R | 0.08 | 52 |
| GG vs. CG/CC | 0.54 (0.36–0.81) | 2.96 | 0.003 | F | 0.27 | 22 |
| ESCC | ||||||
| G vs. C | 0.87 (0.77–0.98) | 2.29 | 0.020 | F | 0.69 | 0 |
| GG vs. CC | 0.54 (0.34–0.84) | 2.70 | 0.007 | F | 0.15 | 47 |
| CG vs. CC | 0.87 (0.68–1.11) | 1.14 | 0.260 | R | 0.08 | 60 |
| GG/CG vs. CC | 0.88 (0.77–1.01) | 1.76 | 0.080 | F | 0.23 | 32 |
| GG vs. CG/CC | 0.64 (0.30–1.37) | 1.15 | 0.250 | R | 0.09 | 59 |
OR, odds ratio; CI, confidence interval; ESCC, esophageal squamous cell carcinoma; vs, versus; R, random effect model; F, fixed effect model; Ph, P-value of Q test for heterogeneity test.