Table 5.
An alternative model for assessing correlates of immunologic health (mean CD4:CD8 ratio >1.0) in 496 HIV-1 SCs.
| Mean CD4:CD8 ratio >1.0 in the 3–24 months period |
||||
|---|---|---|---|---|
| Factors in the joint modelc | Subjects | ORd | 95% CId | Adjusted P |
| Age > 40 years | 75 | 1.13 | 0.60–2.13 | 0.704 |
| Female sex | 185 | 1.15 | 0.72–1.84 | 0.569 |
| HLA-A*74:01 | 63 | 2.01 | 1.09–3.68 | 0.025 |
| HIV-1 subtype A1 | 183 | 1.74 | 1.02–2.95 | 0.042 |
| HIV-1 subtype C | 215 | 1.00 | – | – |
| Other HIV-1 subtypes (not A1 or C) | 98 | 1.89 | 1.02–3.50 | 0.045 |
| Low VL (<10,000) | 140 | 2.62 | 1.61–4.26 | <0.0001 |
| High VL (>100,000) | 91 | 0.52 | 0.23–1.15 | 0.106 |
aHIV-1 subtype replaces geography as a covariate; three subjects with missing information for viral subtype are excluded; one of them has HLA-A*74:01.
bOverall AUC = 0.70, P < 0.0001 for the model.
cReference groups for several multi-entry factors are listed in Table 3.
dEstimates of OR and 95% CI have been adjusted for all factors in the model.