Figure 2.

Dominant effect of CaM on inhibition of AP-evoked vesicular release probability p_v. (A,B) Simulation results for different presynaptic Ca²⁺ buffer mixtures, color codes are shown on the top left in (A). (A) Time courses for [Ca²⁺] (bottom left), vesicular release rate (top right), and cumulative vesicular release probability p_v(t) (bottom right) for a representative VGCC—Ca²⁺ sensor coupling distance d = 40 nm. (B) Dependencies of peak [Ca²⁺] at release sensor (top) and p_v (bottom) on distance d. (C) Relative contributions of the N- and C-lobes of CaM to inhibition of p_v at different distances d. CB was absent in this set of simulations.