Table 1.

Categorization, distribution, and sources of included experimental data.

	Papers	Values	Sources
Calcium regulation
Entry	2	12	Johnson et al. (2011), Quinlan et al. (2011)
Sensitivity	2	11	Pieri et al. (2003), Damiano et al. (2006)
Sink	6	14	Pieri et al. (2003), Damiano et al. (2006), Igoudjil et al. (2011), Milanese et al. (2011), Pesaresi et al. (2011), Tradewell et al. (2011)
Concentration	9	26	Carri et al. (1997), Kruman et al. (1999), Beers et al. (2001), Goos et al. (2007), Guatteo et al. (2007), Milanese et al. (2011), Nutini et al. (2011), Panov et al. (2011), Tradewell et al. (2011)
Mitochondrial mechanisms
Complex I	1	3	Loizzo et al. (2010)
Enzyme activity	5	49	Leclerc et al. (2001), Jung et al. (2002), Mattiazzi et al. (2002), Wendt et al. (2002), Gunther et al. (2004)
COX	1	4	Kirkinezos et al. (2005)
Cytochrome C	5	11	Guégan et al. (2001), Jung et al. (2002), Liu et al. (2002), Kirkinezos et al. (2005), Damiano et al. (2006)
Cellular respiration
Adenosine triphosphate (ATP)	4	21	Browne et al. (2006), Ferri et al. (2008), Mali and Zisapel (2009), Peixoto et al. (2013)
Adenosine diphosphate (ADP)	2	18	Leclerc et al. (2001), Browne et al. (2006)
Respiration rate	7	20	Gunther et al. (2004), Damiano et al. (2006), Cassina et al. (2008), Igoudjil et al. (2011), Panov et al. (2011), Miquel et al. (2012), Zhao et al. (2012)
Oxidative Regulation
8-hydroxy-2′-deoxyguanosine, 8OH2′dG	1	4	Fang et al. (2010)
Hydrogen peroxide, H2O2	5	7	Singh et al. (1998), Liu et al. (1999, 2009), Takamiya et al. (2003), Kloppel et al. (2010)
Malondialdehyde (MDA), C3H4O2	5	36	Hall et al. (1998), Liu et al. (1999), Fang et al. (2010), Miana-Mena et al. (2011), Seo et al. (2011)
Heat shock proteins (HSP)	5	26	Vleminckx et al. (2002), Batulan et al. (2003), Maatkamp et al. (2004), Jaarsma et al. (2008), Crippa et al. (2010)

There are four major categories of measures: intracellular calcium, mitochondrial mechanisms, cellular respiration, and oxidative regulation). Sub-categories of measures, as defined in the Methods, are listed under each category along with the number of included unique articles and extracted data points. Each data point represents a paired SOD1 G93A and wild type mouse assessment at a discrete time point.