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. 2015 Jul 1;6:648. doi: 10.3389/fmicb.2015.00648

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Copyright © 2015 Fernandez-López, Ruiz, de la Cruz and Moncalián.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of whole cell biosensors (WCBs) based on repressor (A), aporepressor (B), or activator (C) transcription factors (TFs). Binding of TF to its operator (TFO) within the promoter region of the reporter gene affects RNApol activity and thus the signal associated to the reporter protein (green stars). The presence of the analyte (effector molecule) modifies the interaction of TF with TFO and changes the amount of reporter protein produced.