Table 3.

One-component TFs with antibiotic effectors.

Effector	Regulator	Regulated system	PDB	Reference
TetRF
Tetracycline	TetR	TetA efflux pump	2TRT	Hinrichs et al. (1994)
Chloramphenicol	TtgR	TtgABC efflux pump	2UXP	Alguel et al. (2007)
Actinorhodin	ActR	ActA efflux pump	3B6A	Willems et al. (2008)
Ethionamine boosters	EthR	EthA flavoprotein monooxygenase	1T56,	Dover et al. (2004)
Simocyclinone	SimR	SimX efflux pump	2Y30	Le et al. (2010)
MarRF
Salicylate, Tetracycline, Chloramphenicol	MarR	MarA activation of AcrAB-TolC multidrug efflux system	1JGS	Alekshun et al. (2001)
Peroxide stress	MexR	Multidrug efflux pump	1LNW	Lim et al. (2002)
Kanamycin	SAR2349	Uncharacterized	4EM0	Chang et al. (2013)
Streptomycin	TcaR	GlcNAc production, biofilm formation	4EJW	Chang et al. (2013)
Nalidixic acid	EmrR	Multidrug resistance pump		Xiong et al. (2000)