Fig. 8.

Adoptive transfer of Treg cells rescues IL10 production in Il10^−/− mice after renal IR injury. C57BL/6 mice underwent IR by unilateral renal pedicle clamping for 45 min, followed by reperfusion (WT). Treg cells were isolated and purified from spleens of C57BL/6 mice, and then injected intravenously into Il10^−/− mice (IL-10-KO) at 18 h before IR induction. The level of IL10 in Il10^−/− was comparable with the kidneys in WT-IR on days 1, 3 and 7. Data are presented as mean±s.d. (n=6 mice). There was no significant difference in IL10 levels between wild type and Il10^−/− mice.