Fig. 1.

Ferritin light chain rescues the rough-eye phenotype caused by Aβ expression but has no effect on the equivalent phenotypes caused by tau, polyQ or TDP43. Compared with control flies (A), the expression of one (B) or two (C) transgenes encoding Aβ₄₂ Arctic caused a rough-eye phenotype when expressed with GMR-gal4. The expression of FerLCH had no effect on the controls (A′) but significantly reduced the rough-eye phenotype in flies expressing Aβ (B′,C′). By contrast, similar co-expression of FerLCH with tau R406W, polyQ or TDP43 did not rescue the rough-eye phenotype (D-F′).