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. 2015 Jul 1;8(7):657–667. doi: 10.1242/dmm.019042

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© 2015. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Position-dependent effects of His>Ala substitutions on Aβ toxicity in a non-oxidising environment. (A) His>Ala substitutions had strong position-dependent effects on fly longevity. The H13A substitution increased, and the H14A substitution decreased, the median survival. The H6A substitution did not have an effect alone; however, when combined with either H13A or H14A, H6A was able to potentiate the effect of the second mutation. (B) There was no correlation between the Tango aggregation propensity score for each peptide and the corresponding median survival of the flies expressing these variants. Flies were crossed at 25°C and maintained at 29°C after hatching. Differences in median survival were tested for significance using the Mann–Whiney test (ns, not significant; *P<0.5, **P<0.01, ***P<0.001). Error bars show s.d.