Table II.
Fold changes in the miRNA expression in DN mice, as determined by qPCR and microarray analyses.
| miRNAs | qPCRa | miRNA arrayb |
|---|---|---|
| Downregulated miRNAs | ||
| miRNA-215 | −4.23 | −5.11 |
| miRNA-346 | −8.12 | −8.20 |
| miRNA-200a | −12.32 | −13.76 |
| miRNA-200b | −14.13 | −10.22 |
| miRNA-200c | −13.11 | −7.75 |
| miRNA-141 | −6.14 | −8.13 |
| miRNA-21 | −2.55 | −4.76 |
| miRNA-45 l | −1.89 | −4.12 |
| miRNA-709 | −2.33 | −5.54 |
| miRNA-187 | −7.32 | −6.93 |
| Upregulated miRNAs | ||
| miRNA-29c | 3.45 | 5.67 |
| miRNA-192 | 2.11 | 4.35 |
| miRNA-216a | 1.98 | 5.76 |
| miRNA-166 | 10.12 | 8.20 |
| miRNA-17 | 5.44 | 6.45 |
| miRNA-377 | 7.88 | 10.12 |
| miRNA-196a | 4.65 | 4.32 |
| miRNA-98 | 2.35 | 4.03 |
a
qPCR results were calculated using the 2−∆∆CT method
b
microarray results represent the ratios of the DN/control. miRNA, microRNA; DN, diabetic nephropathy; qPCR, quantitative polymerase chain reaction.