Table III.
Kaplan-Meier analysis of mTTP based on the presence and severity of adverse events.
| Variable | Patients, n | mTTP, days | χ2 | P-value |
|---|---|---|---|---|
| Severity of adverse events | ||||
| No or mild | 19 | 141 | 5.079 | 0.024 |
| Moderate or severe | 31 | 279 | ||
| HFSR | ||||
| Without | 21 | 172 | 6.643 | 0.010 |
| With | 29 | 312 | ||
| Fatigue | ||||
| Without | 23 | 210 | 1.600 | 0.206 |
| With | 27 | 203 | ||
| Diarrhea | ||||
| Without | 30 | 178 | 1.649 | 0.193 |
| With | 20 | 298 | ||
| Hypertension | ||||
| Without | 31 | 203 | 0.041 | 0.804 |
| With | 19 | 210 | ||
mTTP was calculated by Kaplan-Meier method and the differences in mTTP were evaluated using log-rank test (P<0.05 was considered statistically significant). mTTP, median time to progression; HFSR, hand-foot skin reaction.