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AAT in the airways acts as both an anti-oxidant (A) and anti-protease (B) thereby preventing the pro-inflammatory activity of both on local production of cytokines and chemoattractants. In addition AAT blocks the autocrine activity of TNF also impairing cytokine and adhesion molecule up regulation (C) AAT also down regulates Neutrophil chemotactic response (D) leading to less tissue damage by migrating cells (E). AAT, alpha-1-antitrypsin.
