Table V.
Associations of rs2075650 of TOMM40 or rs273909 of SLC22A4 with the clinical parameters among corresponding controls for hypertension, dyslipidemia, diabetes mellitus or chronic kidney disease.
| Clinical parameter | Genotype | P-value (dominant) | P-value (recessive) | ||
|---|---|---|---|---|---|
| Controls for hypertension | |||||
| TOMM40 (rs2075650) | AA | AG | GG | ||
| Systolic blood pressure, mmHg | 121±11 | 122±11 | 116±10 | 0.9519 | 0.0782 |
| Diastolic blood pressure, mmHg | 71±9 | 71±9 | 69±12 | 0.5835 | 0.6733 |
| Mean blood pressure, mmHg | 88±9 | 88±9 | 85±10 | 0.7415 | 0.2788 |
| Pulse pressure, mmHg | 50±11 | 51±10 | 47±12 | 0.3384 | 0.2738 |
| SLC22A4 (rs273909) | TT | TC | CC | ||
| Systolic blood pressure, mmHg | 121±11 | 126±10 | 128 | 0.0659 | 0.6491 |
| Diastolic blood pressure, mmHg | 71±9 | 72±10 | 78 | 0.8114 | 0.4374 |
| Mean blood pressure, mmHg | 88±9 | 90±9 | 95 | 0.3947 | 0.3570 |
| Pulse pressure, mmHg | 50±11 | 54±19 | 50 | 0.0805 | 0.9611 |
| Controls for dyslipidemia | |||||
| TOMM40 (rs2075650) | AA | AG | GG | ||
| Serum triglycerides, mmol/l | 1.27±0.74 | 1.31±0.72 | 1.33±0.66 | 0.1505 | 0.1883 |
| Serum LDL-cholesterol, mmol/l | 2.68±0.62 | 2.74±0.62 | 2.76±0.66 | 0.0811 | 0.4884 |
| Serum HDL-cholesterol, mmol/l | 1.39±0.39 | 1.37±0.37 | 1.30±0.38 | 0.3865 | 0.2344 |
| SLC22A4 (rs273909) | TT | TC | CC | ||
| Serum triglycerides, mmol/l | 1.29±0.74 | 1.18±0.57 | ND | 0.1587 | ND |
| Serum LDL-cholesterol, mmol/l | 2.70±0.63 | 2.83±0.56 | ND | 0.1461 | ND |
| Serum HDL-cholesterol, mmol/l | 1.38±0.39 | 1.40±0.36 | ND | 0.3983 | ND |
| Controls for diabetes mellitus | |||||
| TOMM40 (rs2075650) | AA | AG | GG | ||
| Fasting plasma glucose, mmol/l | 5.17±0.87 | 5.17±0.85 | 5.24±0.83 | 0.9055 | 0.5534 |
| SLC22A4 (rs273909) | TT | TC | CC | ||
| Fasting plasma glucose, mmol/l | 5.18±0.87 | 5.06±0.72 | 6.69±0.20 | 0.4405 | 0.0228a |
| Controls for chronic kidney disease | |||||
| TOMM40 (rs2075650) | AA | AG | GG | ||
| Serum creatinine, µmol/l | 61.1±12.9 | 60.8±12.3 | 64.0±12.3 | 0.9623 | 0.0783 |
| eGFR (ml/min/1.73 m2) | 80.6±16.6 | 80.0±20.7 | 79.6±17.5 | 0.2028 | 0.6268 |
| SLC22A4 (rs273909) | TT | TC | CC | ||
| Serum creatinine, µmol/l | 61.2±12.8 | 60.4±11.4 | ND | 0.6562 | ND |
| eGFR (ml/min/1.73 m2) | 80.4±17.9 | 77.6±15.6 | ND | 0.7419 | ND |
a
P<0.05. LDL, low-density lipoprotein; HDL, high-density lipoprotein; eGFR, estimated glomerular filtration rate; ND, not determined; TOMM40, translocase of outer mitochondrial membrane 40 homolog gene; SLC22A4, solute carrier family 22, member 4 gene. Data are compared between the two groups (dominant or recessive model) by the Mann-Whitney U test.