Figure 2.

Pulmonary arteriole remodeling was attenuated by rosiglitazone in pulmonary arterial hypertension rats. Compared with the (A) control group, (B) MCT induced pulmonary vascular remodeling, (C) which was attenuated by rosiglitazone treatment (hematoxylin and eosin staining; original magnification, x200). The (D) %MT and (E) %WA were significantly decreased when administered with rosiglitazone (5 mg/kg/day) (n=6). Data represent mean ± standard error of the mean. *P<0.05 and **P<0.01 vs. control; ^#P<0.05 vs. MCT-treated group. Rosi, rosiglitazone; MCT, monocrotaline; Con, control; %MT, percentage of medial wall thickness; %WA, percentage of wall area.