Table I.
Serum enzymes assay in different treatment groups.
| Group | ALT (IU/l) | AST (IU/l) | Creatinine (µmol/l) |
|---|---|---|---|
| VEH | 83.02±12.01 | 91.11±11.20 | 0.73±0.07 |
| APAP | 800.10±27.11a | 1320.41±32.02a | 3.21±0.20a |
| APAP + NAC | 452.23±15.03a,b | 789.72±22.10a,b | 0.42±0.03b |
| APAP + TAK | 588.33±23.02a,b | 757.32±33.13a,b | 0.42±0.04a,b |
Data presented are mean ± standard deviation.
a
P<0.05 vs. the VEH group.
b
P<0.05 vs. the APAP group. ALT, alanine transaminase; AST, aspartate transaminase; VEH, vehicle; APAP, acetaminophen; NAC, N-acetyl cysteine; TAK, TAK-242.