Table II.
Selected studies on head and neck cancer patients with RICNP.
| Authors (year) | Country | RT time period | Tumor side | No. of patients | RT technique | Total dose | CTX (%) | Median FU (years) | RICNP (%) | Most frequently affected CNs | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sanguineti et al (1997) | USA | 1954–1992 | NPC | 378 | 2D | 58–76 Gya | 0.0 | 10 | 8.0 | NA | (8) |
| Lin et al(2002) | China | Since 1968 | NPC | NA | 2D | 70–79.2 Gya | NA | NA | 19 patients collected from a large sample - no quantitative analysis | XIIb | (15) |
| King et al(1998) | China | Prior to 1995 | NPC | 387 | 2D | >66 Gya | NA | for patients with RICNP: 3 | 4.3 | XII only | (4) |
| Sumitsawan et al (2009) | Thailand | 2003–2005 | NPC | 200 | NA | 69 Gya | 72.5 | NA | 6.5 | NA | (9) |
| Luk et al(2013) | China | 1998–2007 | NPC | 965 | 3DCRT 73.4% IMRT 26.6% | 66–70 Gya | NA | 8.9 | 3.7 | XIIb | (3) |
| Huang et al (2013) | USA | 2000–2005 | OPC | 3 | 3DRT, IMRT | 70.4–75.88 Gya | 66.6 | 8–13 | 100.0 | X, XI, XII | (16) |
| Rong et al (2012) | China | 1994–2006 | NPC | 328 | 2-D | 60–80 Gya | NA | 11.3 | 21.9 | Lower CNb | (1) |
| Kong et al (2011) | China, Singapore | 1962–1995 | NPC | 317 | 2D/60Co/BT boost | 71 Gy (90.5% conventional, 9.5% hyperfract.) | 14.2 | 11.4 | 30.9 | Lower CNb | (2) |
| He et al (2012) | China | 1995–2002 | NPC | 158 | 2D/60Co | 78 hyperfract. | 0.0 | 7.5 | 11.0 | XIIb | (5) |
| Bakst et al (2011) | USA | 2002–2007 | NPC | 25 | IMRT | 70.2 Gy hypofract. | 100.0 | 2.75 | 4.0 | XII only | (6) |
| Fua et al (2007) | Malaysia | 2004–2008 | NPC | 176 | 3DCRT | 66–70 Gya | 16.5 | 5 | 2.5 | NA | (7) |
| Present study | Switzerland | 2002–2012 | All | 188 necks | SIB-IMRT | >65 Gya | 82.0 | 5.9 | 0.5 | XII | |
| Total | 2,479 | Mean: 7.3 | Mean: 9.7 |
a
Normofractionation or fractionation not further described.
b
Lower and upper CNs. RICNP, radiation-induced cranial nerve palsy; RT, radiotherapy; CTX, chemotherapy; NPC, nasopharyngeal cancer; OPC, oropharyngeal cancer; NA, not available; IMRT, intensity-modulated RT; 3DCRT, 3-dimensional conformal RT; FU, follow-up; CN, cranial nerve.