Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Jul 1;2:36. doi: 10.3389/fmolb.2015.00036

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Lamprakis, Stocker and Cascella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Protein ligand Interactions in the α-TTP-PI(3,4)P₂ complex from MD. (A) Structure of the relaxed complex. The mobile gate and interacting region are evidenced in green and orange, respectively. (B1) comparison of the orientation of the fatty acid tails of PI(3,4)P₂ after relaxation (tan licorice) with the position of α-Tol (yellow licorice) in the binding cavity from PDB: 1R5L (Meier et al., 2003). The cyan wireframe represents the area of the cavity that in our MD simulations remains occupied by water, and which corresponds to the location of the hydrophilic moiety of α-Tol. (B2) position of the phosphorylated head of PI(3,4)P₂ (in tan and red licorice) and surrounding basic amio acids (in cyan and blue licorice).