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. 2015 Jul 1;2:36. doi: 10.3389/fmolb.2015.00036

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Copyright © 2015 Lamprakis, Stocker and Cascella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time series of the binding/unbinding of α-TTP to a model plasma membrane during CG MD simulations. (A) α-TTP recognizes and binds to a PIP₂ molecule (in purple licorice) on a mixed DOPC/DOPE/PIP₂ lipid bilayer. (B) After incorporation of PIP, α-TTP detaches from the DOPC/DOPE/PIP₂ lipid bilayer (Residues belonging to the basic patch of α-TTP are drawn in blue licorice).