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. 2015 Jul 1;2:36. doi: 10.3389/fmolb.2015.00036

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Copyright © 2015 Lamprakis, Stocker and Cascella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction of α-TTP with the plasma membrane. In the figures, the membrane surface is represented by a white surface. The two N-terminal helices that interact with the membrane are highlighted in cyan and blue, the mobile gate in green, and neighboring motif in organge. the loop/short-helix motif at the C-terminal part of the mobile gate which provides both contacts to PIP₂ and to the membrane is colored in purple. The α-Tol molecule bound to the protein is depicted in yellow licorice. the heads of PIP₂ are also depicted in tan licorice. (A1) structure of the DOPC/DOPE/PtdIns(4,5)P₂ membrane system; (B1) PtdIns(3,4)P₂ membrane. (A2,B2) snapshots from MD highlighting the topological distribution of the residues in the basic patch of the protein around PIP₂ when they are inserted into the membrane.