Figure 1.

Effects of dracorhodin perchlorate (DP) treatment on cell viability and the cell cycle in SK-MES-1 cells. (A) Chemical structure of DP. (B) Effect of DP treatment on the growth of SK-MES-1 cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cells were treated with different concentrations of DP (0, 10, 20, 40, 80 and 160 µmol/l) for 24 and 48 h. (C) Analysis of the cell cycle using propidium iodide staining followed by flow cytometric analysis. Cells were treated with 40 and 80 µM DP for 24 h. (D) Cell cycle phase distribution. Data are expressed as the mean ± standard deviation of three independent experiments. *P<0.05 vs. control.