Table II.
Association between polymorphisms in the LMP2 and LMP7 genes and the risk of gastric cancer.
| Incidence, n (%) | ||||||
|---|---|---|---|---|---|---|
| Genotype | Gastric cancer | Control | Crude OR (95% CI) | P-value | Adjusted OR (95% CI)a | P-value |
| Total | 502 (100.00) | 502 (100.00) | ||||
| LMP2–60 | ||||||
| Arg/Arg | 338 (67.3) | 335 (66.7) | 1 | 1 | ||
| Arg/His | 151 (30.1) | 155 (30.9) | 0.97 (0.74–1.27) | 0.799 | 0.97 (0.74–1.27) | 0.819 |
| His/ His | 13 (2.6) | 12 (2.4) | 1.07 (0.48–2.39) | 0.861 | 1.08 (0.48–2.41) | 0.857 |
| Arg/His + His/His | 164 (32.7) | 167 (33.3) | 0.97 (0.75–1.27) | 0.840 | 0.98 (0.75–1.27) | 0.856 |
| Allelic | ||||||
| Arg | 827 (82.4) | 825 (82.3) | 0.99 (0.78–1.24) | 0.907 | ||
| His | 177 (17.6) | 179 (17.8) | ||||
| HWE | 0.424 | 0.228 | ||||
| LMP7–145 | ||||||
| Gln/Gln | 310 (61.8) | 349 (69.5) | 1 | 1 | ||
| Gln/Lys | 169 (33.7) | 141 (28.1) | 1.35 (1.03–1.77) | 0.030 | 1.32 (1.00–1.73) | 0.049 |
| Lys/Lys | 23 (4.6) | 12 (2.4) | 2.16 (1.06–4.41) | 0.035 | 2.13 (1.03–4.39) | 0.041 |
| Gln/Lys + Lys/Lys | 192 (38.3) | 153 (30.5) | 1.41 (1.09–1.84) | 0.010 | 1.38 (1.06–1.80) | 0.017 |
| Allelic | ||||||
| Gln | 789 (78.6) | 839 (83.6) | 1.39 (1.11–1.74) | 0.004 | ||
| Lys | 215 (21.4) | 165 (16.4) | ||||
| HWE | 0.995 | 0.613 | ||||
a
Adjusted for age, gender, smoking status, residence, hypertension and diabetes. OR, odds ratio; CI, confidence interval; LMP, low molecular weight protein; HWE, Hardy-Weinberg equilibrium.