Table IV.
Stratified analyses of the genotypes of the LMP2 and LMP7 genes in patients with gastric cancer and control individuals.
| LMP2-60 Arg/His + His/His vs. Arg/Arg | LMP7-145 Gln/Lys + Lys/Lys vs. Gln/Gln | |||||||
|---|---|---|---|---|---|---|---|---|
| Variable | Gastric cancer, n (%) | Control, n (%) | Allelic OR (95% CI)a | P-value | Gastric cancer, n (%) | Control, n (%) | Allelic OR (95% CI)a | P-value |
| Median age, years | ||||||||
| ≤59 | 91 (18.1)/156 (31.1) | 89 (17.7)/172 (34.3) | 1.13 (0.78–1.63) | 0.508 | 97 (19.3)/150 (29.9) | 88 (17.5)/173 (34.5) | 1.25 (0.87–1.80) | 0.235 |
| >59 | 73 (14.5)/182 (36.3) | 78 (15.5)/163 (32.5) | 0.83 (0.56–1.22) | 0.336 | 95 (18.9)/160 (31.9) | 65 (12.9)/176 (35.1) | 1.57 (1.06–2.31) | 0.024 |
| Gender | ||||||||
| Females | 45 (9.0)/93 (18.5) | 52 (10.4)/105 (20.9) | 0.97 (0.59–1.60) | 0.918 | 46 (9.2)/92 (18.3) | 47 (9.4)/110 (21.9) | 1.21 (0.73–2.00) | 0.465 |
| Males | 119 (23.7)/245 (48.8) | 115 (22.9)/230 (45.8) | 0.97 (0.71–1.33) | 0.842 | 146 (29.1)/218 (43.4) | 106 (21.1)/239 (47.6) | 1.48 (1.08–2.03) | 0.015 |
| Smoking status | ||||||||
| Smokers | 42 (8.4)/81 (16.1) | 28 (5.6)/57 (11.4) | 1.07 (0.59–1.95) | 0.822 | 49 (9.8)/74 (14.7) | 32 (6.4)/53 (10.6) | 1.15 (0.64–2.08) | 0.634 |
| Non-smokers | 122 (24.3)/257 (51.2) | 139 (27.7)/278 (55.4) | 0.95 (0.71–1.28) | 0.756 | 143 (28.5)/236 (47.0) | 121 (24.1)/296 (59.0) | 1.48 (1.10–1.99) | 0.010 |
| Residence | ||||||||
| Rural | 91 (18.1)/198 (39.4) | 86 (17.1)/179 (35.7) | 0.95 (0.66–1.36) | 0.767 | 110 (21.9)/179 (35.7) | 82 (16.3)/183 (36.5) | 1.29 (0.90–1.85) | 0.160 |
| Urban | 73 (14.5)/140 (27.9) | 81 (16.1)/156 (31.1) | 0.99 (0.67–1.47) | 0.951 | 82 (16.3)/131 (26.1) | 71 (14.1)/166 (33.1) | 1.46 (0.98–2.17) | 0.061 |
a
Adjusted for age, gender, smoking status, residence, hypertension and diabetes. OR, odds ratio; CI, confidence interval; LMP, low molecular weight protein.